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KMID : 0385219940040020137
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Korean Journal of Gerontology
1994 Volume.4 No. 2 p.137 ~ p.142
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Increased Expression of SI00β Protein in Rabbit Brain Tissue Following Aluminum Exposure
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Ju Won-Kyu
Yu Il-Je
Kim Yong-Sun
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Abstract
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Aluminum induced neurofibrillary tangles formation in rabbit brain is very useful animal model for research of Alzheimer’s disease (AD). The presence of abnormal levels of neurotrophic factors in AD is one possible explanation for the increased concentration of aggregates of overgrown neurites io neuritic plaques of AD. The data presented here demonstrate that the levels of Sl00β protein and mRNA were significantly elevated in extracts of brain samples from aluminum injected groups compared to those of control groups. The cells containing the increased Sl00β were reactive astrocytes. A generalization of our findings is that when elevated Sl00β expression accompanies the gliosis observed in neurodegenerative disease and aluminum injected animals, this will be an associated increase in neurotrophic activity result in abnormal neuritic morphology.
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KEYWORD
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rabbit brain, aluminum, neurofibrillary tangle, Sl00β protein
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